Metabolism Alprazolam is thoroughly metabolized in humans, generally by cytochrome P450 3A4 (CYP3A4), to 2 important Energetic metabolites while in the plasma: 4-hydroxyalprazolam and ?-hydroxyalprazolam. The plasma circulation amounts of the two Energetic metabolites are fewer than 4% of the guardian. The documented relative potencies in benzodiaz